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Peteris Trapencieris

Latvian Institute of Organic Synthesis, Latvia

Title: Natural products for epigenetic histone methylation

Biography

Biography: Peteris Trapencieris

Abstract

A new concept of multitarget epigenetic drugs for anticancer treatment is where one of the enzymes is from field of epigenetics. We do offer to check natural compound (olefins, polyphenols, terpenes) dual inhibitors, where both of them are influencing epigenetic reactions - phosphorylation, methylation or acetylation. We have started to employ the most specific histone (H3K27Me3) methylation target EZH2 and its active natural complex PRC2. First in vitro testing experiments have shown good EZH2 inhibition by some natural polyphenols and triterpenes.