Traditional & Alternative Medicine

Biography

Biography: Sungwook Chae

Abstract

Due to development of health science and medicine, life expectancy has increased. Therefore, more people have been showing dermatological concerns in recent years. Chronic exposure of human skin to solar ultraviolet (UV) radiation causes photoaging which accelerates the visible ageing of skin together with intrinsic aging. Many studies showed that naturally occurring compounds are known to have anti-photoaging effects via oral administraion. The market for cosmetics that are natural is converging with the growth of foods and nutritional products catering to “beauty from within” to create great opportunities for anti-wrinkle treatment. And topical treatment like cosmetics is also important because of their pharmaceutical benefits. Our study started from this concept; these two types of topical cosmetics and nutricosmetic need to be combined to work in a complementary and alternative way, which replenish the body’s own collagen by providing essential sources and enhancing epidermal function. Our lead material (KIOM-HB10) used in this study showed anti-wrinkle properties in terms of skin thickness, and changes in collagen fibers in HR-1 hairless mice. In the in vivo results, UVB-induced mean length and mean depth of skin wrinkle, epidermal thickening, and damage to collagen fiber were restored by oral administration of KIOM-HB10. In vitro results showed that KIOM-HB10 inhibited UVB-induced damage in HaCaT human keratinocyte by lowering the level of matrix metalloproteinase (MMPs).